Brain & Neuroimaging Seminar: Igor Meglinski, "Photonics-Based Technologies in Functional Diagnosis"
Friday, April 26, 2019
0215 Edward St. John Center
Perspectives of Photonics-Based Technologies in Functional Diagnosis of Brain and Neuroimaging
University of Oulu, Finland
We utilize the latest light techniques and optical engineering solutions to advance brain research, offering the potential of state-of-the-art diagnostics and imaging techniques. An example of such a technique – Transcranial Functional Optical Imaging (TOVI) for imaging of cerebral vasculature in vivo. In vivo imaging of cerebral vasculature is highly vital for clinicians and medical researchers alike. For a number of years non-invasive optical-based imaging of brain vascular network by using standard fluorescence-based spectroscopic approach considered as impossible. We developed a robust non-invasive optical-based imaging approach that allows visualize major cerebral vessels at the high temporal and spatial resolution. The developed technique is simple to use, utilizes dynamic light scattering and standard fluorescent dyes, inexpensive imaging and computation procedures. The ability to clearly visualize middle cerebral artery and other major vessels of brain vascular network, as well as the measurements of dynamics of blood flow in normal tissues and in brain tumours are presented. The developed imaging approach has a great potential in neuroimaging and can significantly expand the capabilities of preclinical functional studies of brain and notably contribute for analysis of brain malformations. In addition, a combined use of Circularly-Polarized-Light–based technique that is able to assess quantitatively amyloid plaques and identify irregular cells (neurons), e.g. in focal cortical dysplasias (FCD) samples, and TOVI approach are discussed and presented.
Igor Meglinski is a full professor leading the Biophotonics and Biomedical Diagnostics research at the University of Oulu, Finland. He obtained PhD degree in Biophysics and Biomedical Optics at the interface between University of Pennsylvania/USA and Saratov State University/Russia in 1997, under the supervision of Professor Britton Chance and Professor Valery Tuchin. His research interests lie at the interface between physics, biomedical engineering, medicine and biological sciences, focusing on the development of new sensors and non-invasive optical diagnostic/imaging techniques and their applications in medicine & biology, material sciences, combustion, pharmacy, environmental monitoring, agricultural, food processing and the health care industries. Prof. Meglinski is author and/or co-author of over 300 papers in peer-reviewed scientific journal, conference proceedings and book chapter and delivered over 600 presentations at a range of conferences, symposia and workshops, including over 280 invited and plenary lectures and keynote talks. He is Chartered Physicist (CPhys) and Chartered Engineer (CEng), Fellow of the Institute of Physics (FInstP), Senior Member of IEEE and Fellow of SPIE.